Interrogating gatekeeper genes
DTEx™ is NoAb BioDiscoveries’ proprietary microarray-based technology, which allows investigators the ability to survey the effects of drug treatment on the expression level of genes involved in ADME pathways. As ‘gatekeepers’ for drugs and xenobiotic compounds, the transporters and cytochrome P450s have a direct influence on the pharmacokinetics and pharmacodynamics of administered drugs. DTEx™ technology provides a profile of the expression levels of these genes in biological systems.
DTEx™ technology is applicable throughout the drug discovery process. From target validation to post-market studies, DTEx™ can provide valuable information on the biological response to therapeutic compounds, thereby helping drug development take shape.
DTEx™ is NoAb BioDiscoveries’ proprietary microarray-based technology, which allows investigators the ability to survey the effects of drug treatment on the expression level of genes involved in ADME pathways. As ‘gatekeepers’ for drugs and xenobiotic compounds, the transporters and cytochrome P450s have a direct influence on the pharmacokinetics and pharmacodynamics of administered drugs. DTEx™ technology provides a profile of the expression levels of these genes in biological systems.
DTEx™ technology is applicable throughout the drug discovery process. From target validation to post-market studies, DTEx™ can provide valuable information on the biological response to therapeutic compounds, thereby helping drug development take shape.
