In Vivo Studies
Pharmacokinetics determinations in rats and mice
Pharmacokinetics studies in:
Pharmacokinetics determinations in rats and mice
Pharmacokinetics studies in:
- Carotid artery and jugular vein catheterized rats with intra-duodenal dosing
- Carotid artery, jugular vein and bile duct catheterized rats and guinea pigs
- Hepatoportal vein catheterized rats
- Serial collection of plasma and cerebrospinal fluid (CSF) in freely moving rats.
- Microdialysis (coming soon)
In Vitro Assays
DTEx™ Services
- Cell permeability assays
- Plasma protein binding
- Cytochrome P450 enzyme subtype inhibition studies
- Metabolic stability in hepatocytes
- Metabolic stability in liver subcellular fractions
- Plasma stability assays
- Cytotoxicity assays
- Customer specific screening assays (radiochemical, fluorescent, etc.)
DTEx™ Services
- DTEx™ – Overview.
- DTEx™ – ABC: Gene expression profiling of 48 human efflux drug transporters.
- DTEx™ – ADME: Gene expression profiling of efflux and uptake transporters, Phase I and II metabolic enzymes and nuclear X receptor-transcription factors.
- DTEx™ – Custom: Gene expression profiling of client-selected genes from NoAb’s DTEx™ gene inventory.
